Name	Known for
Michelle Jenner Isabel de Castilla Isabel de Castilla See fewer	Isabel (2011)
Rodolfo Sancho Fernando de Aragón Fernando de Aragón See fewer	Isabel (2011)
Ramon Madaula Gonzalo Chacón (as Ramón Madaula) Gonzalo Chacón (as Ramón Madaula) See fewer	Isabel (2011)
Francesc Garrido Juan Rodríguez de Fonseca Juan Rodríguez de Fonseca See fewer	The Sea Inside (2004)
Lluís Soler Hernando de Talavera Hernando de Talavera See fewer	Luz de Mar (2022)
Jordi Díaz Andrés de Cabrera Andrés de Cabrera See fewer	Isabel (2011)
Jorge Bosch Alejandro VI Alejandro VI See fewer	Los lobos de Washington (1999)
José Pedro Carrión Luis de Tremoille Luis de Tremoille See fewer	Medea 2 (2006)
Abel Folk Francisco de Busleyden Francisco de Busleyden See fewer	Xtrems (2009)
Irene Escolar Juana I de Castilla Juana I de Castilla See fewer	An Autumn Without Berlin (2015)
Raúl Mérida Felipe el Hermoso Felipe el Hermoso See fewer	Un golpe de suerte (2009)
Ainhoa Santamaría Beatriz de Bobadilla Beatriz de Bobadilla See fewer	Parallel Mothers (2021)
Héctor Carballo Carlos VIII Carlos VIII See fewer	Isabel (2011)
Iván Hermés Manuel I de Portugal Manuel I de Portugal See fewer	Al salir de clase (1997)
María Cantuel Princesa Isabel Princesa Isabel See fewer	The Zone (2017)
Úrsula Corberó Margarita de Austria Margarita de Austria See fewer	Money Heist (2017)
Adrián Lamana Príncipe Juan (as Adrian Lamana) Príncipe Juan (as Adrian Lamana) See fewer	The Devil's Backbone (2001)
Nacho Aldeguer César Borgia César Borgia See fewer	The Mallorca Files (2019)
Jorge Calvo Bernardo Boyl Bernardo Boyl See fewer	Isabel (2011)
Sergio Peris-Mencheta Gonzalo Fernández de Córdoba Gonzalo Fernández de Córdoba See fewer	Resident Evil: Afterlife (2010)
Fernando Guillén Cuervo Gutierre Gómez de Fuensalida Gutierre Gómez de Fuensalida See fewer	Quantum of Solace (2008)
Eusebio Poncela Francisco Jiménez de Cisneros Francisco Jiménez de Cisneros See fewer	El accidente (2017)
Nuria Gallardo Beatriz de Braganza y Portugal Beatriz de Braganza y Portugal See fewer	Voyage to Nowhere (1986)
Jesús Castejón Actor Actor See fewer	Captain Alatriste: The Spanish Musketeer (2006)
Lolo Diego Mensajero Mensajero See fewer	Vis a Vis: El Oasis (2020)
Jesús Gurpegui Actor Actor See fewer	Isabel (2011)
Asier Hormaza Actor Actor See fewer	Agur (2014)
Alberto Iglesias Actor Actor See fewer	Filón 340 (2011)
Carlos Troya Actor Actor See fewer	Red Flags (2024)
José Manuel Valdés Núñez (uncredited) Núñez (uncredited) See fewer	Noctem (2017)